Page 137 - handbook 20162017

Faculty of Science Handbook, Session 2016/2017

SIJ 3013 NATURAL PRODUCT BIOCHEMISTRY AND 2. Introduction to Protein Structure. Carl Branden and
DRUG DISCOVERY John Tooze.Garland Publishing Inc.

This course is designed to provide an overview to the field
of natural product and drug discovery. This course covers SIJ 3015 EPIGENETICS AND RNA BIOLOGY
the different types of natural product and their usages,
positive/negative effects of its usage, important classes of This course introduces a new field in genetics known as
chemical compounds, mechanism of reaction, methods epigenetics. It will cover topics involving DNA methylation
and suitable experimental techniques that can be applied and histone modification and how it controls gene
to isolate and identify bioactive component. Drug expression. It will also cover chromatin remodelling and
discovery component will emphasis on how to bring a drug genomic imprinting. The course will also discuss RNA
from concept to market, introduction to drug approval related biology processes.
process, clinical trials, drug safety guidelines, and ethical
issues. Research and development that will lead to the Assessment Methods:
invention of potential commercialisable product will also Continuous Assessment: 40%
be discussed using selected example. Final Examination: 60%
Assessment Methods: Medium of Instruction:
Continuous Assessment: 40% English
Final Examination: 60%
Soft Skills:
Medium of Instruction: CT3, LL2
English
Main References:
Soft Skills: 1. Snustad. (2012) Principles of genetics. 7 Edition
th
CT3, LL2 John Wiley
2. Devlin. (2013) Textbook of biochemistry. John Wiley
Main References: 3. Stryer. (2012) Biochemistry. Freeman
1. Recent Trends in Biotechnology and Therapeutic 4.
Application of Medicinal Plants (2013) Mohd Shahid, Watson. (2012) Molecular biology of the gene.
Pearson/Benjamin Cumming.
Anwar Shahzad, Abida Malik, Aastha Sahai; Springer 5.
2. Drug Discovery and Evaluation: Pharmacological Lewin. (2012) Genes VIII. Oxford University Press.
rd
Assays, 3 ed, edited by H.G. Vogel; Springer
Reference.
3. Bioactive Natural Products – Detection, Isolation and SIJ 3016 BIOCHEMISTRY OF CANCER
Structural Determination (2007), Steven M. Colegate,
Russell J. Molyneux; CRC Press This course will cover the origins of cancer and the
nd
4. Natural Products from Plants (2006) 2 ed. Leland J genetic and cellular basis for cancer. It will examine the
Cseke, Ara Kirakosyan, Peter B Kaufman, Sara L factors that have been implicated in triggering cancers; the
Warber, James A Duke, Harry L Brielmann; Taylor & intercellular interactions involved in cancer proliferation;
Francis current treatments for cancer and how these are
5. Natural Product Chemistry for Drug Discovery (2009), designed; and future research and treatment directions for
Anthony D Buss, Mark S Butler; RSC Publishing cancer therapy.
Assessment Methods:
SIJ 3014 MOLECULAR STRUCTURAL BIOLOGY Continuous Assessment: 40%
Final Examination: 60%
The course will introduce to students the structure of
proteins at all levels, and how this relates to function. A Medium of Instruction:
non-mathematical introduction of the basic principle of X- English
ray crystallography and other techniques used in structural
studies. Nuclear magnetic resonance (NMR) is the second Soft Skills:
most important technique for determining the three- CS3, CT3, LL3
dimensional structure of macromolecules. Electron
Microscopy (EM) is a technique that is complementary to Main References:
X-ray crystallography as it enables the study of non- 1. Robert A. Weinberg (2013). The Biology of Cancer.
crystalline, very large or transient macromolecular Garlend Science.
structures. This course also introduces some 2. Kleinsmith LJ (2006). Principles of Cancer Biology.
methodologies for protein purification for structural Pearson.
studies. It also examines the importance of protein-protein 3. Bronchud, MH. (2004). Principles of Molecular
interactions and some techniques used for the study. Oncology (2nd Ed). Humana Press, New Jersey.

Assessment Methods:
Continuous Assessment: 40%
Final Examination: 60%
BACHELOR OF SCIENCE IN ENVIRONMENTAL
Medium of Instruction: MANAGEMENT PROGRAMME
English

Soft Skills: Career Prospects
CS2, CT3,TS1, LL2 Graduates from this Programme have the opportunity to
contribute to the nation’s development as managers,
Main References: consultants, academicians, scientists, officers, planners,
1. Physical Biochemistry: Principles and Applications. auditors, law enforcers or educators in the environment
2000. David Sheehan. Wiley .

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