Page 210 - FINAL_HANDBOOK_20242025

Basic principles of medicinal chemistry; categories of drugs and SIC3033 NATURAL PRODUCTS AND BIOSYNTHESIS
basis of drug action: drug-receptor model; drug design and
development; drug and pro-drug metabolism; pharmacokinetics Classification of natural products. Biosynthesis of natural products,
and pharmacodynamics. such as alkaloids, terpenoids, flavonoids, lignans and glycosides.
Separation strategies and spectroscopic methods for structural
Application of selected important heterocyclic compounds in elucidation of natural products.
medicinal chemistry. Biochemical constraints and investigation techniques: biosynthetic
reagents, enzymes, biochemical assays and application of isotopic
Assessment Weightage: labelling (esp. in conjunction with 13C NMR) in the study of
Continuous assessment: 40% biosynthetic processes.
Final examination: 60%
Assessment Weightage:
Continuous assessment: 40%
SIC3031 ELECTROCHEMISTRY Final examination: 60%

Background of electrochemical cell, type of electrodes, liquid
junction potential, concentrations of electrolyte. Basic SIC3034 ORGANIC SYNTHESIS
electrochemistry on electrode reaction, electrode kinetics, Butler-
Volmer equation, Tafel anode and cathode equation, overpotential, Retrosynthetic analysis and design of multistep syntheses.
mass transport and Nernst diffusion layer. Electrochemical double Selectivity in synthesis. Synthesis of acyclic and cyclic compounds.
layer, electrode-electrolyte interface, Faradaic and non-Faradaic Use of organometallic reagents in syntheses. Asymmetric
currents. synthesis; selected examples from classical and contemporary
syntheses.
Potentiostatic and galvanostatic electrochemical methods including
cyclic voltammetry method in diagnostic mechanism (E, EC, CE or Assessment Weightage:
ECE reactions), chronoamperometry, coulometry, polarography Continuous assessment: 40%
and stripping voltammetry methods. Final examination: 60%

Surface confined electrochemical processes and applications in
electroanalytical field in sensor. Electrosynthesis in industry focus SIC3035 MECHANISTIC ORGANIC CHEMISTRY
on the synthesis of inorganic chemicals: aluminium extraction and
copper purification; and electrosynthesis of organic compounds Reactive intermediates in organic chemistry including carbocations,
(such as phthalide, cyanoacetic acids) through various methods. free radicals, carbenes, nitrenes, and radical- ions. Chemistry of
free radicals: reactions and mechanisms of free radicals including
Assessment Weightage: abstraction, addition, rearrangement, cyclization and fragmentation;
Continuous assessment: 40% applications of radical reactions in organic synthesis; reactions of
Final examination: 60% carbenes, carbenoids, nitrenes, and ion-radicals, and applications
SIC3032 ENVIRONMENTAL CHEMISTRY in synthesis. Formation, stability, and rearrangements of
carbocations; tandem and cascade cyclizations. Mechanistic details
Introduction to Environmental Chemistry Atmosphere of selected classes of organic reactions such as nucleophilic
Characteristics, reaction and reactivities, ozone depletion, Global substitution, hydrolysis, polar rearrangements, electron-transfer
climate change, Criteria pollutants, photochemical smog, reactions, photochemical reactions.
Atmospheric particulates, acid rain, Toxic air pollutants and control.
Pericyclic reactions: molecular orbitals; conservation of orbital
Hydrosphere symmetry in concerted reactions; theory (frontier orbital method,
Characteristic of ocean and freshwater, distribution of chemical use of correlation diagrams, aromatic transition state approach) and
species (single variable diagram and pE-pH diagram), dissolved applications of electrocyclic reactions, sigmatropic rearrangements,
gases, major water quality parameters, water pollution and analysis, and cycloadditions, including tandem and cascade processes, in
water pollutants, water treatment. organic synthesis.

Lithosphere Assessment Weightage:
Soil formation, physical and chemical characteristic of soils, Continuous assessment: 40%
environmental problems and reactions associated with soils, solid Final examination: 60%
waste management.
Fate and Transport of pollutants in the environment Introduction to
major analytical techniques for environmental analysis, including SIC3036 PHYSICAL ORGANIC CHEMISTRY
sample preparation, spectroscopic and chromatographic methods.
Data treatment. Quality control and quality assurance. Application of physical organic concepts in the determination of
Introduction to Environmental Management: Sustainable organic reaction mechanisms; kinetics and thermodynamics;
development, Environmental quality act (1974), Environmental stereochemistry & conformational analysis; solvent effects; non-
management strategies, Environmental impact assessment (EIA). kinetic and kinetic isotope effects; sonochemistry; organic surface
reactions. Approximation, catalysis in molecules: covalent, general
Assessment Weightage: acid-base and pseudophase.
Continuous assessment: 50%
Final examination: 50% Assessment Weightage:
Continuous assessment: 40%
Final examination: 60%