Page 187 - buku panduan 20192020
P. 187
Faculty of Science Handbook, Session 2019/2020
Physical methods in Inorganic Chemistry Reactive intermediates in organic chemistry including
Spectroscopic techniques: vibrational, EPR/ESR, carbocations, free radicals, carbenes, nitrenes, and
31
19
multinuclear NMR (eg. P, F, 119 Sn) radical-ions. Chemistry of free radicals: reactions and
Vibrational: Introduction, theoretic background, selection mechanisms of free radicals including abstraction,
rules, applications. addition, rearrangement, cyclization and fragmentation;
applications of radical reactions in organic synthesis;
EPR/ESR: background, introduction, electronic structure reactions of carbenes, carbenoids, nitrenes, and ion-
of atoms and open-shell ions, spin-orbit coupling, g- radicals, and applications in synthesis. Formation, stability,
values, Zeeman interaction, hyperfine coupling, hyperfine and rearrangements of carbocations; tandem and cascade
anisotropy, applications cyclizations. Mechanistic details of selected classes of
Multinuclear NMR: Introduction, theoretic background, organic reactions such as nucleophilic substitution,
applications hydrolysis, polar rearrangements, electron-transfer
reactions, photochemical reactions. Pericyclic reactions:
Non-spectroscopic techniques: molecular orbitals; conservation of orbital symmetry in
Concept of magnetic dipoles and magnetic susceptibility, concerted reactions; theory (frontier orbital method, use of
Ideal paramagnets (Curie Law) and weakly interacting correlation diagrams, aromatic transition state approach)
paramagnets (Curie-Weiss), types of magnetic response, and applications of electrocyclic reactions, sigmatropic
experimental techniques of magnetic susceptibility rearrangements, and cycloadditions, including tandem and
measurements in solution and solid state. cascade processes, in organic synthesis.
Other related methods, eg. xray diffractometry, PXRD,
mass spectrometry. Assessment Methods:
Practical: 25%
Assessment Methods: Continuous assessment: 15%
Practical: 25% Final examination: 60%
Continuous assessment: 15%
Final examination: 60% Medium of instruction:
English
Medium of instruction:
English Soft skills:
CT1 – 3
Soft skills:
CT1 – 3 References:
1. F. A. Carey and R. J. Sundberg, Advanced Organic
th
References: Chemistry, Part B: Reactions and Synthesis, 5 . Ed.,
1. C. M. A. Brett and A. M. O. Brett, Electrochemistry Plenum Press, New York & London, 2010.
Principles, Methods and Applications, Oxford Uni. Press 2. E.L. Eliel, S.H. Wilen, L.M. Mander, Stereochemistry of
Inc., 1993. Organic Compounds, John Wiley & Sons Canada, Ltd.,
2. P. T. Kissinger and W. R. Heinemmen, Laboratory 1994.
Techniques in Electroanalytical Chemistry, Marcel 3. T.H. Lowry, K.S. Richardson, Mechanism and Theory in
rd
Dekker Inc., 1984. Organic Chemistry, 3 Ed., Benjamin-Cummings
3. D. Pletcher and F.C. Walsh, Industrial Electrochemistry, Publishing Company, 1987.
Blackie Academic and Professional, 1993. 4. J.M. Harris and C.C. Wamser, Fundamentals of Organic
4. D. B. Hibbert, Introduction to Electrochemistry, Reaction Mechanisms, Wiley & Sons, 1976.
MacMillan Press Ltd., 1993. 5. Warren, S.; Wyatt, P. Workbook for Organic Synthesis:
5. K. B. Oldham, J. C. Myland, A. M. Bond, The Disconnection Approach, 2nd ed., John Wiley &
Electrochemical Science and Technology: Sons, Ltd.: United Kingdom, 2009.
Fundamentals and Applications, John Wiley & Sons, 6. R. B. Woodward, R. Hoffmann, The Conservation of
Ltd, 2011. Orbital Symmetry, Academic Press Inc., 2014 (reprint).
SID3002 ADVANCED ORGANIC CHEMISTRY SID3003 ADVANCED PHYSICAL CHEMISTRY
Brief introduction to organic synthesis: disconnections and Molecular Quantum Mechanics
retrosynthetic analysis. Approximate methods: variational method and time
independent Perturbation theory; Electronic structure of
Use of compounds incorporating main group elements (B, molecules: Born-Oppenheimer approximation, molecular
S, Si, P, mainly; and, Sn, Se, Al) in organic functional orbital theory, valence-bond theory, Huckel molecular
group transformations; orbital theory, electron configuration, Slater determinant,
Use of transition metals in C-C bond formation (e.g., Heck, angular momentum coupling, molecule terms, spin-orbit
Suzuki, Stille, Negishi, Sonogashira, Kumada, McMurry, and other interactions, symmetry, molecule spectra and
etc.); Alkene metathesis. selection rules; Hartree-Fock self-consistent-field method,
other ab initio methods and hybrid systems.
Stereochemistry: Introduction to asymmetric synthesis,
axial chirality, importance of enantiopure compounds, Molecular Approach to Thermodynamics
chiral pool; selected examples of asymmetric synthesis The fundamentals of statistical mechanics from the
including hydroboration, hydride reduction, hydrogenation, definitions of molecular interactions giving a set of energy
epoxidation, dihydroxylation, and aminohydroxylation, use levels for N-molecule systems. Statistical treatment to
of chiral auxiliaries in enolate alkylation, crossed-aldol obtain a distribution of the most probable energy
additions, and Diels-Alder cycloaddition, etc. configuration or Boltzmann distribution. Introduction to
partition function of molecules containing all the
Selected total syntheses of biologically-active natural information on N-molecule systems. Ensemble concept,
products of contemporary significance (e.g., taxoids; incorporated partition function and its relation to
macrolides, e.g., epothilones; Catharanthus bisindoles; thermodynamic properties. Intermolecular forces for
prostanoids; steroids; etc.).
173