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Faculty of Science Handbook, Session 2019/2020


               Physical methods in Inorganic Chemistry        Reactive  intermediates  in  organic  chemistry  including
               Spectroscopic   techniques:   vibrational,   EPR/ESR,   carbocations,  free  radicals,  carbenes,  nitrenes,  and
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               multinuclear NMR (eg.  P,  F,  119 Sn)         radical-ions.  Chemistry  of  free  radicals:  reactions  and
               Vibrational:  Introduction,  theoretic  background,  selection   mechanisms  of  free  radicals  including  abstraction,
               rules, applications.                           addition,  rearrangement,  cyclization  and  fragmentation;
                                                              applications  of  radical  reactions  in  organic  synthesis;
               EPR/ESR:  background,  introduction,  electronic  structure   reactions  of  carbenes,  carbenoids,  nitrenes,  and  ion-
               of  atoms  and  open-shell  ions,  spin-orbit  coupling,  g-  radicals, and applications in synthesis. Formation, stability,
               values, Zeeman interaction, hyperfine coupling, hyperfine   and rearrangements of carbocations; tandem and cascade
               anisotropy, applications                       cyclizations.  Mechanistic  details  of  selected  classes  of
               Multinuclear  NMR:  Introduction,  theoretic  background,   organic  reactions  such  as  nucleophilic  substitution,
               applications                                   hydrolysis,   polar   rearrangements,   electron-transfer
                                                              reactions,  photochemical  reactions.  Pericyclic  reactions:
               Non-spectroscopic techniques:                  molecular  orbitals;  conservation  of  orbital  symmetry  in
               Concept of magnetic dipoles and magnetic susceptibility,   concerted reactions; theory (frontier orbital method, use of
               Ideal  paramagnets  (Curie  Law)  and  weakly  interacting   correlation  diagrams,  aromatic  transition  state  approach)
               paramagnets (Curie-Weiss), types of magnetic response,   and  applications  of  electrocyclic  reactions,  sigmatropic
               experimental  techniques  of  magnetic  susceptibility   rearrangements, and cycloadditions, including tandem and
               measurements in solution and solid state.      cascade processes, in organic synthesis.
               Other  related  methods,  eg.  xray  diffractometry,  PXRD,
               mass spectrometry.                             Assessment Methods:
                                                              Practical:           25%
               Assessment Methods:                            Continuous assessment:    15%
               Practical:            25%                      Final examination:      60%
               Continuous assessment:    15%
               Final examination:      60%                    Medium of instruction:
                                                              English
               Medium of instruction:
               English                                        Soft skills:
                                                              CT1 – 3
               Soft skills:
               CT1 – 3                                        References:
                                                              1. F.  A.  Carey  and  R.  J.  Sundberg,  Advanced  Organic
                                                                                                  th
               References:                                     Chemistry,  Part  B:  Reactions  and  Synthesis,  5 .  Ed.,
               1. C.  M.  A.  Brett  and  A.  M.  O.  Brett,  Electrochemistry   Plenum Press, New York & London, 2010.
                 Principles, Methods and Applications, Oxford Uni. Press   2. E.L. Eliel, S.H. Wilen, L.M. Mander, Stereochemistry of
                 Inc., 1993.                                   Organic Compounds, John Wiley & Sons Canada, Ltd.,
               2. P.  T.  Kissinger  and  W.  R.  Heinemmen,  Laboratory   1994.
                 Techniques  in  Electroanalytical  Chemistry,  Marcel   3. T.H. Lowry, K.S. Richardson, Mechanism and Theory in
                                                                                 rd
                 Dekker Inc., 1984.                            Organic  Chemistry,  3   Ed.,  Benjamin-Cummings
               3. D. Pletcher and F.C. Walsh, Industrial Electrochemistry,   Publishing Company, 1987.
                 Blackie Academic and Professional, 1993.     4. J.M. Harris and C.C. Wamser, Fundamentals of Organic
               4. D.  B.  Hibbert,  Introduction  to  Electrochemistry,   Reaction Mechanisms, Wiley & Sons, 1976.
                 MacMillan Press Ltd., 1993.                  5. Warren, S.; Wyatt, P. Workbook for Organic Synthesis:
               5. K.  B.  Oldham,  J.  C.  Myland,  A.  M.  Bond,   The Disconnection Approach, 2nd ed., John Wiley &
                 Electrochemical   Science   and   Technology:   Sons, Ltd.: United Kingdom, 2009.
                 Fundamentals  and  Applications,  John  Wiley  &  Sons,   6. R. B. Woodward, R. Hoffmann, The Conservation of
                 Ltd, 2011.                                    Orbital Symmetry, Academic Press Inc., 2014 (reprint).


               SID3002  ADVANCED ORGANIC CHEMISTRY            SID3003  ADVANCED PHYSICAL CHEMISTRY

               Brief introduction to organic synthesis: disconnections and   Molecular Quantum Mechanics
               retrosynthetic analysis.                       Approximate  methods:    variational  method  and  time
                                                              independent  Perturbation  theory;    Electronic  structure  of
               Use of compounds incorporating main group elements (B,   molecules:  Born-Oppenheimer  approximation,  molecular
               S,  Si,  P,  mainly;  and,  Sn,  Se,  Al)  in  organic  functional   orbital  theory,  valence-bond  theory,  Huckel  molecular
               group transformations;                         orbital  theory,  electron  configuration,  Slater  determinant,
               Use of transition metals in C-C bond formation (e.g., Heck,   angular  momentum  coupling,  molecule  terms,  spin-orbit
               Suzuki,  Stille,  Negishi,  Sonogashira,  Kumada,  McMurry,   and  other  interactions,  symmetry,  molecule  spectra  and
               etc.); Alkene metathesis.                      selection rules; Hartree-Fock self-consistent-field method,
                                                              other ab initio methods and hybrid systems.
               Stereochemistry:  Introduction  to  asymmetric  synthesis,
               axial  chirality,  importance  of  enantiopure  compounds,   Molecular Approach to Thermodynamics
               chiral  pool;  selected  examples  of  asymmetric  synthesis   The  fundamentals  of  statistical  mechanics  from  the
               including hydroboration, hydride reduction, hydrogenation,   definitions of molecular interactions giving a set of energy
               epoxidation, dihydroxylation, and aminohydroxylation, use   levels  for  N-molecule  systems.    Statistical  treatment  to
               of  chiral  auxiliaries  in  enolate  alkylation,  crossed-aldol   obtain  a  distribution  of  the  most  probable  energy
               additions, and Diels-Alder cycloaddition, etc.    configuration or    Boltzmann distribution.  Introduction to
                                                              partition  function  of  molecules  containing  all  the
               Selected  total  syntheses  of  biologically-active  natural   information  on  N-molecule  systems.    Ensemble  concept,
               products  of  contemporary  significance  (e.g.,  taxoids;   incorporated  partition  function  and  its  relation  to
               macrolides,  e.g.,  epothilones;  Catharanthus  bisindoles;   thermodynamic  properties.  Intermolecular  forces  for
               prostanoids; steroids; etc.).

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