Page 167 - Handbook Bachelor Degree of Science Academic Session 20202021

Faculty of Science Handbook, Session 2019/2020

Non-spectroscopic techniques: rearrangements, and cycloadditions, including tandem and
Concept of magnetic dipoles and magnetic susceptibility, cascade processes, in organic synthesis.
Ideal paramagnets (Curie Law) and weakly interacting
paramagnets (Curie-Weiss), types of magnetic response, Assessment Methods:
experimental techniques of magnetic susceptibility Practical: 25%
measurements in solution and solid state. Continuous assessment: 15%
Other related methods, eg. xray diffractometry, PXRD, Final examination: 60%
mass spectrometry.
Medium of instruction:
Assessment Methods: English
Practical: 25%
Continuous assessment: 15% References:
Final examination: 60% 1. F. A. Carey and R. J. Sundberg, Advanced Organic
th
Chemistry, Part B: Reactions and Synthesis, 5 . Ed.,
Medium of instruction: Plenum Press, New York & London, 2010.
English 2. E.L. Eliel, S.H. Wilen, L.M. Mander, Stereochemistry of
Organic Compounds, John Wiley & Sons Canada, Ltd.,
References: 1994.
1. C. M. A. Brett and A. M. O. Brett, Electrochemistry 3. T.H. Lowry, K.S. Richardson, Mechanism and Theory in
Principles, Methods and Applications, Oxford Uni. Press Organic Chemistry, 3 Ed., Benjamin-Cummings
rd
Inc., 1993. Publishing Company, 1987.
2. P. T. Kissinger and W. R. Heinemmen, Laboratory 4. J.M. Harris and C.C. Wamser, Fundamentals of Organic
Techniques in Electroanalytical Chemistry, Marcel Reaction Mechanisms, Wiley & Sons, 1976.
Dekker Inc., 1984. 5. Warren, S.; Wyatt, P. Workbook for Organic Synthesis:
3. D. Pletcher and F.C. Walsh, Industrial Electrochemistry, The Disconnection Approach, 2nd ed., John Wiley &
Blackie Academic and Professional, 1993. Sons, Ltd.: United Kingdom, 2009.
4. D. B. Hibbert, Introduction to Electrochemistry, MacMillan 6. R. B. Woodward, R. Hoffmann, The Conservation of
Press Ltd., 1993. Orbital Symmetry, Academic Press Inc., 2014 (reprint).
5. K. B. Oldham, J. C. Myland, A. M. Bond, Electrochemical
Science and Technology: Fundamentals and SID3003 ADVANCED PHYSICAL CHEMISTRY
Applications, John Wiley & Sons, Ltd, 2011.
Molecular Quantum Mechanics
Approximate methods: variational method and time
SID3002 ADVANCED ORGANIC CHEMISTRY independent Perturbation theory; Electronic structure of
molecules: Born-Oppenheimer approximation, molecular
Brief introduction to organic synthesis: disconnections and orbital theory, valence-bond theory, Huckel molecular
retrosynthetic analysis. orbital theory, electron configuration, Slater determinant,
angular momentum coupling, molecule terms, spin-orbit
Use of compounds incorporating main group elements (B, and other interactions, symmetry, molecule spectra and
S, Si, P, mainly; and, Sn, Se, Al) in organic functional group selection rules; Hartree-Fock self-consistent-field method,
transformations; other ab initio methods and hybrid systems.
Use of transition metals in C-C bond formation (e.g., Heck,
Suzuki, Stille, Negishi, Sonogashira, Kumada, McMurry, Molecular Approach to Thermodynamics
etc.); Alkene metathesis. The fundamentals of statistical mechanics from the
definitions of molecular interactions giving a set of energy
Stereochemistry: Introduction to asymmetric synthesis, levels for N-molecule systems. Statistical treatment to
axial chirality, importance of enantiopure compounds, chiral obtain a distribution of the most probable energy
pool; selected examples of asymmetric synthesis including configuration or Boltzmann distribution. Introduction to
hydroboration, hydride reduction, hydrogenation, partition function of molecules containing all the information
epoxidation, dihydroxylation, and aminohydroxylation, use on N-molecule systems. Ensemble concept, incorporated
of chiral auxiliaries in enolate alkylation, crossed-aldol partition function and its relation to thermodynamic
additions, and Diels-Alder cycloaddition, etc. properties. Intermolecular forces for various systems
including liquid and soft matters. Simple applications of this
Selected total syntheses of biologically-active natural method in various chemical problems.
products of contemporary significance (e.g., taxoids;
macrolides, e.g., epothilones; Catharanthus bisindoles; Application
prostanoids; steroids; etc.).  Chemical Kinetics and the Dynamics of Reactions
Diffusion controlled reactions. Activated complex theory
Reactive intermediates in organic chemistry including and reactions in solutions. The dynamics of molecular
carbocations, free radicals, carbenes, nitrenes, and radical- collisions. The kinetics of fast reactions.
ions. Chemistry of free radicals: reactions and mechanisms Thermodynamics and kinetics of adsorption. Structure,
of free radicals including abstraction, addition, Stability and reactivity in different state of matter. The
rearrangement, cyclization and fragmentation; applications properties of nonequilibrium.
of radical reactions in organic synthesis; reactions of
carbenes, carbenoids, nitrenes, and ion-radicals, and  Photochemistry
applications in synthesis. Formation, stability, and Kinetics of photophysical and photochemical processes.
rearrangements of carbocations; tandem and cascade Timescales of photophysical process, quantum yield,
cyclizations. Mechanistic details of selected classes of mechanism of decay of excited states, quenching.
organic reactions such as nucleophilic substitution, Applications of photochemistry: photosynthesis,
hydrolysis, polar rearrangements, electron-transfer photosynthesis, photobiology and photomedicine.
reactions, photochemical reactions. Pericyclic reactions:
molecular orbitals; conservation of orbital symmetry in Assessment Methods:
concerted reactions; theory (frontier orbital method, use of Practical: 25%
correlation diagrams, aromatic transition state approach) Continuous assessment: 15%
and applications of electrocyclic reactions, sigmatropic Final examination: 60%

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