Page 247 - handbook 20152016

Faculty of Science Handbook, Session 2015/2016

Soft skills: References:
CT1 – 3 1. Francis A. Carey and Richard J. Sundberg, Advanced
th
Organic Chemistry, Part B: Reactions and Synthesis, 4 .
References: Ed., Plenum Press, New York & London, 2002.
6. C. M. A. Brett and A. M. O. Brett, Electrochemistry 2. E.L. Eliel, S.H. Wilen, L.M. Mander, Stereochemistry of
Principles, Methods and Applications, Oxford Uni. Press Organic Compounds, John Wiley & Sons Canada, Ltd.,
Inc., 1993. 1994.
7. P. T. Kissinger and W. R. Heinemmen, Laboratory 3. T.H. Lowry, K.S. Richardson, Mechanism and Theory in
rd
Techniques in Electroanalytical Chemistry, Marcel Dekker Organic Chemistry, 3 Ed., Benjamin-Cummings
Inc., 1984. Publishing Company, 1987.
8. D. Pletcher and F.C. Walsh, Industrial Electrochemistry, 4. J.M. Harris and C.C. Wamser, Fundamentals of Organic
Blackie Academic and Professional, 1993. Reaction Mechanisms, Wiley & Sons, 1976.
9. D. B. Hibbert, Introduction to Electrochemistry, MacMillan
Press Ltd., 1993.
10. K. B. Oldham, J. C. Myland, A. M. Bond, SID3003 ADVANCED PHYSICAL CHEMISTRY
Electrochemical Science and Technology: Fundamentals
and Applications, John Wiley & Sons, Ltd, 2011. Molecular Quantum Mechanics
Approximate methods: variational method and time
independent Perturbation theory; Electronic structure of
molecules: Born-Oppenheimer approximation, molecular
SID3002 ADVANCED ORGANIC CHEMISTRY orbital theory, valence-bond theory, Huckel molecular orbital
theory, electron configuration, Slater determinant, angular
Brief introduction to organic synthesis: disconnections and momentum coupling, molecule terms, spin-orbit and other
retrosynthetic analysis. interactions, symmetry, molecule spectra and selection
rules; Hartree-Fock self-consistent-field method, other ab
Use of compounds incorporating main group elements (B, initio methods and hybrid systems.
S, Si, P, mainly; and, Sn, Se, Al) in organic functional group
transformations; Molecular Approach to Thermodynamics
Use of transition metals in C-C bond formation (e.g., Heck, The fundamentals of statistical mechanics from the
Suzuki, Stille, Negishi, Sonogashira, Kumada, McMurry, definitions of molecular interactions giving a set of energy
etc.); Alkene metathesis. levels for N-molecule systems. Statistical treatment to
obtain a distribution of the most probable energy
Stereochemistry: Introduction to asymmetric synthesis, axial configuration or Boltzmann distribution. Introduction to
chirality, importance of enantiopure compounds, chiral pool; partition function of molecules containing all the information
selected examples of asymmetric synthesis including on N-molecule systems. Ensemble concept, incorporated
hydroboration, hydride reduction, hydrogenation, partition function and its relation to thermodynamic
epoxidation, dihydroxylation, and aminohydroxylation, use of properties. Intermolecular forces for various systems
chiral auxiliaries in enolate alkylation, crossed-aldol including liquid and soft matters. Simple applications of this
additions, and Diels-Alder cycloaddition, etc. method in various chemical problems.

Selected total syntheses of biologically-active natural
products of contemporary significance (e.g., taxoids; Application
macrolides, e.g., epothilones; Catharanthus bisindoles;  Chemical Kinetics and the Dynamics of Reactions
prostanoids; steroids; etc.). Diffusion controlled reactions. Activated complex theory
and reactions in solutions. The dynamics of molecular
Reactive intermediates in organic chemistry including collisions. The kinetics of fast reactions. Thermodynamics
carbocations, free radicals, carbenes, nitrenes, and radical- and kinetics of adsorption. Structure, Stability and
ions. Chemistry of free radicals: reactions and mechanisms reactivity in different state of matter. The properties of
of free radicals including abstraction, addition, nonequilibrium.
rearrangement, cyclization and fragmentation; applications
of radical reactions in organic synthesis; reactions of  Photochemistry
carbenes, carbenoids, nitrenes, and ion-radicals, and Kinetics of photophysical and photochemical processes.
applications in synthesis. Formation, stability, and Timescales of photophysical process, quantum yield,
rearrangements of carbocations; tandem and cascade mechanism of decay of excited states, quenching.
cyclizations. Mechanistic details of selected classes of Applications of photochemistry: photosynthesis,
organic reactions such as nucleophilic substitution, photosynthesis, photobiology and photomedicine.
hydrolysis, polar rearrangements, electron-transfer
reactions, photochemical reactions. Pericyclic reactions: Assessment Methods:
molecular orbitals; conservation of orbital symmetry in Continuous assessment: 15%
concerted reactions; theory (frontier orbital method, use of Practical; 25%
correlation diagrams, aromatic transition state approach) Final examination: 60%
and applications of electrocyclic reactions, sigmatropic
rearrangements, and cycloadditions, including tandem and Medium of instruction:
cascade processes, in organic synthesis. English

Assessment Methods: Soft skills:
Continuous assessment: 15% CT1 – 3
Practical: 25%
Final examination: 60% References:
1. Atkins, P. W. (2010). Physical Chemistry, 9th ed. Oxford
Medium of instruction: University Press, New York.
English 2. Atkins, P. W. (2008). Molecular Quantum Mechanics, 5th
Ed. Oxford University Press, New York.
Soft skills: 3. Lowe, J. P. (1993). Quantum Chemistry, 2nd Ed.
CT1 – 3 Academic Press, New York..

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