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Faculty of Science Handbook, Session 2017/2018

values, Zeeman interaction, hyperfine coupling, hyperfine and rearrangements of carbocations; tandem and cascade
anisotropy, applications cyclizations. Mechanistic details of selected classes of
Multinuclear NMR: Introduction, theoretic background, organic reactions such as nucleophilic substitution,
applications hydrolysis, polar rearrangements, electron-transfer
reactions, photochemical reactions. Pericyclic reactions:
Non-spectroscopic techniques: molecular orbitals; conservation of orbital symmetry in
Concept of magnetic dipoles and magnetic susceptibility, concerted reactions; theory (frontier orbital method, use of
Ideal paramagnets (Curie Law) and weakly interacting correlation diagrams, aromatic transition state approach)
paramagnets (Curie-Weiss), types of magnetic response, and applications of electrocyclic reactions, sigmatropic
experimental techniques of magnetic susceptibility rearrangements, and cycloadditions, including tandem and
measurements in solution and solid state. cascade processes, in organic synthesis.
Other related methods, eg. xray diffractometry, PXRD,
mass spectrometry. Assessment Methods:
Practical: 25%
Assessment Methods: Continuous assessment: 15%
Practical: 25% Final examination: 60%
Continuous assessment: 15%
Final examination: 60% Medium of instruction:
English
Medium of instruction:
English Soft skills:
CT1 – 3
Soft skills:
CT1 – 3 References:
1. Francis A. Carey and Richard J. Sundberg, Advanced
References: Organic Chemistry, Part B: Reactions and Synthesis,
1.C. M. A. Brett and A. M. O. Brett, Electrochemistry 4 . Ed., Plenum Press, New York & London, 2002.
th
Principles, Methods and Applications, Oxford Uni. Press 2. E.L. Eliel, S.H. Wilen, L.M. Mander, Stereochemistry of
Inc., 1993. Organic Compounds, John Wiley & Sons Canada, Ltd.,
2.P. T. Kissinger and W. R. Heinemmen, Laboratory 1994.
Techniques in Electroanalytical Chemistry, Marcel 3. T.H. Lowry, K.S. Richardson, Mechanism and Theory in
Dekker Inc., 1984. Organic Chemistry, 3 rd Ed., Benjamin-Cummings
3.D. Pletcher and F.C. Walsh, Industrial Electrochemistry, Publishing Company, 1987.
Blackie Academic and Professional, 1993. 4. J.M. Harris and C.C. Wamser, Fundamentals of Organic
4.D. B. Hibbert, Introduction to Electrochemistry, Reaction Mechanisms, Wiley & Sons, 1976.
MacMillan Press Ltd., 1993.
5.K. B. Oldham, J. C. Myland, A. M. Bond,
Electrochemical Science and Technology: SID3003 ADVANCED PHYSICAL CHEMISTRY
Fundamentals and Applications, John Wiley & Sons,
Ltd, 2011. Molecular Quantum Mechanics
Approximate methods: variational method and time
independent Perturbation theory; Electronic structure of
SID3002 ADVANCED ORGANIC CHEMISTRY molecules: Born-Oppenheimer approximation, molecular
orbital theory, valence-bond theory, Huckel molecular
Brief introduction to organic synthesis: disconnections and orbital theory, electron configuration, Slater determinant,
retrosynthetic analysis. angular momentum coupling, molecule terms, spin-orbit
and other interactions, symmetry, molecule spectra and
Use of compounds incorporating main group elements (B, selection rules; Hartree-Fock self-consistent-field method,
S, Si, P, mainly; and, Sn, Se, Al) in organic functional other ab initio methods and hybrid systems.
group transformations;
Use of transition metals in C-C bond formation (e.g., Heck, Molecular Approach to Thermodynamics
Suzuki, Stille, Negishi, Sonogashira, Kumada, McMurry, The fundamentals of statistical mechanics from the
etc.); Alkene metathesis. definitions of molecular interactions giving a set of energy
levels for N-molecule systems. Statistical treatment to
Stereochemistry: Introduction to asymmetric synthesis, obtain a distribution of the most probable energy
axial chirality, importance of enantiopure compounds, configuration or Boltzmann distribution. Introduction to
chiral pool; selected examples of asymmetric synthesis partition function of molecules containing all the
including hydroboration, hydride reduction, hydrogenation, information on N-molecule systems. Ensemble concept,
epoxidation, dihydroxylation, and aminohydroxylation, use incorporated partition function and its relation to
of chiral auxiliaries in enolate alkylation, crossed-aldol thermodynamic properties. Intermolecular forces for
additions, and Diels-Alder cycloaddition, etc. various systems including liquid and soft matters. Simple
applications of this method in various chemical problems.
Selected total syntheses of biologically-active natural
products of contemporary significance (e.g., taxoids; Application
macrolides, e.g., epothilones; Catharanthus bisindoles;  Chemical Kinetics and the Dynamics of Reactions
prostanoids; steroids; etc.). Diffusion controlled reactions. Activated complex theory
and reactions in solutions. The dynamics of molecular
Reactive intermediates in organic chemistry including collisions. The kinetics of fast reactions.
carbocations, free radicals, carbenes, nitrenes, and Thermodynamics and kinetics of adsorption. Structure,
radical-ions. Chemistry of free radicals: reactions and Stability and reactivity in different state of matter. The
mechanisms of free radicals including abstraction, properties of nonequilibrium.
addition, rearrangement, cyclization and fragmentation;
applications of radical reactions in organic synthesis;  Photochemistry
reactions of carbenes, carbenoids, nitrenes, and ion- Kinetics of photophysical and photochemical processes.
radicals, and applications in synthesis. Formation, stability, Timescales of photophysical process, quantum yield,

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