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SIC3033 NATURAL PRODUCTS AND Chemistry, New York: Springer
BIOSYNTHESIS 6. Zografos, L. A (2016) From Biosynthesis to Total
Synthesis: Strategies and Tactics for Natural
Classification of natural products. Biosynthesis of Products, Wiley.
natural products, such as alkaloids, terpenoids,
flavonoids, lignans and glycosides. Separation
strategies and spectroscopic methods for structural SIC3035 MECHANISTIC ORGANIC CHEMISTRY
elucidation of natural products.
Reactive intermediates in organic chemistry
Biochemical constraints and investigation including carbocations, free radicals, carbenes,
techniques: biosynthetic reagents, enzymes, nitrenes, and radical- ions. Chemistry of free
biochemical assays and application of isotopic radicals: reactions and mechanisms of free
labelling (esp. in conjunction with 13C NMR) in the radicals including abstraction, addition,
study of biosynthetic processes. rearrangement, cyclization and fragmentation;
applications of radical reactions in organic
Assessment Weightage synthesis; reactions of carbenes, carbenoids,
Continuous assessment 40% nitrenes, and ion-radicals, and applications in
Summative assessment 60% synthesis. Formation, stability, and
rearrangements of carbocations; tandem and
References: cascade cyclizations. Mechanistic details of
1. Dewick, P. M. Medicinal Natural Products - A selected classes of organic reactions such as
Biosynthetic Approach. John Wiley & Sons, 2009. nucleophilic substitution, hydrolysis, polar
2. Fattorusso, E.; Taglialatela-Scafati, O. Modern rearrangements, electron-transfer reactions,
Alkaloids - Structure, Isolation, Synthesis and photochemical reactions.
Biology. Eds.; Wiley-VCH, 2008.
3. Mann, J. Chemical Aspects of Biosynthesis. Oxford Pericyclic reactions: molecular orbitals;
University Press, 1994 conservation of orbital symmetry in concerted
4. Mann, J. Secondary Metabolism. 2nd Ed. Oxford reactions; theory (frontier orbital method, use of
University Press, 1987. correlation diagrams, aromatic transition state
5. Simpson, J. H. Organic Structure Determination approach) and applications of electrocyclic
Using 2-D NMR Spectroscopy - A Problem-Based reactions, sigmatropic rearrangements, and
Approach. Academic Press, 2008. cycloadditions, including tandem and cascade
6. Stefan Berger, S.; Sicker, D. Classics in processes, in organic synthesis.
Spectroscopy, Wiley-VCH, 2009.
Assessment Weightage
Continuous assessment 40%
SIC3034 ORGANIC SYNTHESIS Summative assessment 60%
Retrosynthetic analysis and design of multistep References:
syntheses. Selectivity in synthesis. Synthesis of 1. Richard B. Woodward and Roald Hoffmann, 2014
acyclic and cyclic compounds. Use of (reprint), The Conservation of Orbital Symmetry,
organometallic reagents in syntheses. Asymmetric Academic Press Inc.
synthesis; selected examples from classical and 2. Ian Fleming, (2009), Molecular Orbitals and
contemporary syntheses. Organic Chemical Reactions, Wiley.
3. S. Sankararaman, 2005, Pericyclic Reactions - A
Assessment Weightage Textbook: Reactions, Applications and Theory,
Continuous assessment 40% Wiley- VCH
Summative assessment 60% 4. Sunil Kumar, Vinod Kumar, S.P. Singh, (2015),
Pericyclic Reactions - A Mechanistic and Problem-
References: Solving Approach, Elsevier.
1. Warren, S. & Wyatt, P. (2009) Organic Synthesis: 5. Thomas H. Lowry and Kathleen Schueller
The Disconnection Approach, New York: John Richardson, 1997, Mechanism and Theory in
Wiley & Sons Inc. Organic Chemistry, 3rd Ed., Benjamin-Cummings
2. Overman, E. L. (2010) Organic Reactions, Publishing Company.
Volumes 1- 74, Set, New York: John Wiley & Sons 6. Jonathan Clayden, Nick Greeves, Stuart Warren,
Inc. (2012), Organic Chemistry 2nd ed., Oxford
3. Smith, B. M. & March, J. (2013) March’s Advanced University Press.
Organic Chemistry Reactions, Mechanisms, and
Structure, New York: John Wiley & Sons Inc
4. Nicolaou, K. C. & Sorensen, J. E. (1996) Classics SIC3036 PHYSICAL ORGANIC CHEMISTRY
in Total Synthesis, Wiley-VCH
5. Li, J. J & Corey, E.J (2012) Total Synthesis of Application of physical organic concepts in the
Natural Products: At The Frontiers of Organic determination of organic reaction mechanisms;

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