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Faculty of Science Handbook, Session 2019/2020

SIJ 1002 FUNDAMENTALS OF CHEMISTRY SIJ 2002 STRUCTURE AND FUNCTION OF
BIOMOLECULES
This course covers the basic principles of physical and
organic chemistry with application to biological problems. This course consists of several experiments: isolation
This course is intended primarily for biochemistry majors. methods, general biochemical analysis procedures,
This course will discuss topics on the fundamental demonstration as well as theory regarding the latest
techniques and instrumentation used in the laboratory.
principles of physical chemistry which include chemical Basic diagnostic tests will also be conducted. This course
equilibrium, acidity and basicity, kinetics, thermodynamics will also emphasise quantitative data analysis.
and ligand-protein interaction. Basic principles of organic
chemistry, including fundamental aspects of organic and Assessment Methods:
biological structures and bonding, stereochemistry, the Continuous Assessment: 40%
effect of structure on physical and chemical properties will Practicals: 60%
be discussed. A detailed analysis of organic chemical Medium of Instruction:
reactivity, including reactive intermediates and English
mechanistic principles of the various groups of organic
compounds like alkanes and cycloalkanes, alkenes, Soft Skills:
alkynes, aromatics, alkyl halides, alcohols, ethers, thiols, CT3, LL2
amines, carbonyls and derivatives will be covered.
Main References: th
Assessment Methods: 1. Biochemistry, 7 ed (2012); Lubert M Stryer:
Continuous Assessment: 40% Macmillan Education.
Final Examination: 60% 2. Textbook of biochemistry with clinical correlations,
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6 ed; Ed by Thomas M Devlin; John Wiley & Sons
Medium of Instruction: Inc (downloadable).
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English 3. Biochemistry; 4 ed,(2011) Voet & Voet, Wiley
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4. Biochemistry; 5 Ed, Garrett & Grisham:
Soft Skills: Brooks/Cole Cengage Learning.
CS3, CT3, LL1. 5. A journey from amino acids to proteins; Saad
Tayyab & Amru Nasrulhaq Boyce; Uni Malaya
Main References: Press.
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1. John E. McMurry. (2011). Organic Chemistry, 8
edition. Cengage Learning. Bab 1,3,4,6,7,8,9,10,11. SIJ 2003 ENERGETICS, METABOLISM AND
2. John McMurry. (2012) Organic Chemistry: a biological REGULATION OF CARBOHYDRATE
th
approach, 8 edition. New Jersey: Cengage Learning. AND LIPIDS
Bab 1,3,4,5,6,7,8,9,10,13,14,15,16,18.
nd
3. Alan Cooper. (2012). Biophysical Chemistry, 2 The students will learn the principles of bioenergetics,
edition. RSC Pub, Cambridge. biosynthesis and catabolism of the primary
4. Predrag-Peter Ilich. (2014) Selected Problems in macromolecules, and regulatory mechanisms involved in
Physical Chemistry [e.book]: Strategies and intermediary metabolism.
Interpretations, Springer, Berlin Heidelberg.
5. Gordon G. Hommes (2008) Physical Chemistry for the The course encompasses the following topics: (1)
Biological Sciences, Wiley-Interscience. Concept of energy in metabolism and energy production
by aerobic and anaerobic respiration, and fermentation;
(2) Biosynthesis and catabolism of primary
SIJ 2001 PRINCIPLES OF BIOCHEMICAL ANALYSIS macromolecules (carbohydrate, lipid, sulphur
compounds); (3) Regulation and integration of metabolic
The course contains the quantitative aspects of processes.
Biochemistry where the emphasis will be given to the
areas of acid-base, pH, buffer preparation, titration, Assessment Methods:
enzyme kinetics, bioenergetics and radioactivity. The Continuous Assessment: 40%
course will also include current and “classical” analytical Final Examination: 60%
methods – gels, TLC, qPCR, MS, HPLC, LC-MS
Medium of Instruction:
Assessment Methods: English
Continuous Assessment: 40%
Final Examination: 60% Soft Skills:
CS3, CT3, LL2
Medium of Instruction:
English Main References:
1. Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto
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Soft Skills: Jr and Lubert Stryer (2015). Biochemistry (8 edition).
CS3, CT3, TS2, LL2. New York: W.H. Freeman.
2. Christopher K Mathews, Kensal E van Holde, Dean R
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Main References: Appling (2012). Biochemistry (4 edition). Pearson
1. Principles of Biochemistry, 2013 (4th Edition or later). Education.
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Voet, Voet & Pratt 3. Donald Voet, Judith G. Voet (2011).Biochemistry (4
2. Fundamentals of Biochemical Calculations, Second edition) .New York: John Wiley.
Edition (2007). Krish Moorthy 4. Reginald H. Garrett and Charles M. Grisham (2013).
Biochemistry (5th edition). Brooks/Cole, Cengage
Learning.

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