Page 157 - Handbook Bachelor Degree of Science Academic Session 20202021

Faculty of Science Handbook, Session 2019/2020

SIC2015 ELECTROCHEMISTRY SIC3002 ORGANIC CHEMISTRY III

Background of electrochemical cell, type of electrode, liquid Brief introduction to organic synthesis: disconnections and
junction potential, concentrations of electrolyte. Basic retrosynthetic analysis;
electrochemistry on electrode reaction, electrode kinetics,
Butler-Volmer equation, Tafel anode and cathode equation, Use of compounds incorporating main group elements (B,
overpotential, mass transport, diffusion current and Nernst S, Si, P, mainly; and, Sn, Se, Al) in organic functional group
diffusion layer. Potentiostatic and galvanostatic transformations;
electrochemical methods including chronoamperometry, Use of transition metals in C-C bond formation (e.g., Heck,
coulometry, polarography, cyclic voltammetry and stripping Suzuki, Stille, Negishi, Sonogashira, Kumada, McMurry,
voltammetry methods. Surface confined electrochemical etc.); Alkene metathesis.
processes and applications in electroanalytical field.
Stereochemistry: Introduction to asymmetric synthesis,
Assessment Methods: axial chirality, importance of enantiopure compounds, chiral
Continuous assessment: 30% pool; selected examples of asymmetric synthesis including
Final examination: 70% hydroboration, hydride reduction, hydrogenation,
epoxidation, dihydroxylation, and aminohydroxylation, use
Medium of instruction: of chiral auxiliaries in enolate alkylation, crossed-aldol
English additions, and Diels-Alder cycloaddition, etc.

References: Selected total syntheses of biologically-active natural
1. A. J Bard and L. R. Faulkner, Electrochemical Methods products of contemporary significance (e.g., taxoids;
nd
Fundamental and Application, 2 ed., John Wiley & macrolides, e.g., epothilones; Catharanthus bisindoles;
Sons, 2001. prostanoids; steroids; etc.).
2. D. Pletcher and F. C. Walsh, Industrial Electrochemistry,
Blackie Academic and Profesional, 1993. Physical organic concepts and methods in the
3. P. Monk, Fundamentals of Electroanalytical Chemistry, determination of reaction mechanisms: product studies,
John Wiley & Sons, 2001. intermediates, stereochemistry, energetics and kinetics,
nd
4. J. Wang, Analytical Electrochemistry, 2 ed., John Wiley isotope effects (non-kinetic and kinetic), and, linear free
& Sons, 2000. energy relationships.

Assessment Methods:
SIC3001 INORGANIC CHEMISTRY III Practical: 25%
Continuous assessment: 15%
Organometallic Chemistry: Final examination: 60%
Historical background, Classification/bonding types of
Organometallics Compounds of Transition Elements, Main Medium of instruction:
Group Organometallics & Lanthanides, 18-electron rules, English
Ligands in Organometallics (carbonyl, hydride,
alkyl/alkene, carbene, carbyne, metallocene & fullerene). References:
Spectral (IR, NMR) and x-ray structural analysis. 1. Francis A. Carey and Richard J. Sundberg, Advanced
th
Organometallic reactions. Organic Chemistry, Part B: Reactions and Synthesis, 4 .
ed., Plenum Press, New York & London, 2002.
Reaction kinetics and mechanism of transition metal 2. E. L. Eliel, S. H. Wilen, L. M. Mander, Stereochemistry of
complexes: Organic Compounds, John Wiley & Sons Canada, Ltd.,
Introduction to inorganic reaction mechanism. Dissociative, 1994.
associative and interchange mechanisms. Derivation of the 3. T. H. Lowry, K. S. Richardson, Mechanism and Theory in
rd
rate law based on the above mechanisms. Substitution Organic Chemistry, 3 ed., Benjamin-Cummings
reactions of octahedral, tetrahedral and 5-coordinate Publishing Company, 1987.
systems. Substitution reactions catalysed by acid and base. 4. J. M. Harris and C. C. Wamser, Fundamentals of Organic
Inner-sphere and outer-sphere mechanisms. Reaction Mechanisms, Wiley & Sons, 1976.
nd
5. N. Isaacs, Physical Organic Chemistry, 2 ed., Prentice
Assessment Methods: Hall, 1996.
Practical: 25% 6. S. Warren; P. Wyatt, Workbook for Organic Synthesis:
Continuous assessment: 15% The Disconnection Approach, 2 ed., John Wiley & Sons,
nd
Final examination: 60% Ltd.: United Kingdom, 2009.

Medium of instruction:
English SIC3003 PHYSICAL CHEMISTRY III

References: Molecular Quantum Mechanics
1. C. Elschenbroich and A. Salzer, Organometallics A Approximate methods: variational method and time
nd
concise Introduction, 2 rev., VCH, 1992. independent Perturbation theory; Electronic structure of
2. G. O. Spessard and G. L. Miessler, Organometallic molecules: Born-Oppenheimer approximation, molecular
Chemistry, Prentice Hall, 1997. orbital theory, valence-bond theory, Huckel molecular
3. Gary L. Miessler & Donald A. Tarr, Inorganis Chemistry. orbital theory, electron configuration, Slater determinant,
rd
3 ed., Pearson Prentice Hall, 2004 angular momentum coupling, molecular term symbols,
4. F. A. Cotton and G. Wilkinson, Advanced Inorganic spin-orbit and other interactions, molecule spectra and
Chemistry, John Wiley & Sons, 1972. selection rules; Hartree-Fock self-consistent-field method,
5. Journal of Organometallic Chemistry. other ab initio methods and hybrid systems.
6. Fred Basolo and Ralph G Pearson, Mechanism of
Inorganic Reactions. A study of metal complexes in Molecular Approach to Thermodynamics
nd
solution, 2 ed., John Wiley & Sons, 1967. The fundamentals of statistical mechanics from the
7. R. A. Henderson, The mechanisms of reactions at definitions of molecular interactions giving a set of energy
transition metal sites, Oxford Science Publications, 1993. levels for N-molecule systems. Statistical treatment to
156