Page 89 - Handbook Bachelor Degree of Science Academic Session 20202021

Faculty of Science Handbook, Academic Session 2020/2021

Main References: SIL 2008 MOLECULAR GENETICS
1. Baxevanis,A.D.&Ouelette,F.(2005). Bioinformatics: A
Practical Guide to the Analysis of Gene and Proteins. This course includes topics involved in eukaryotic DNA
3 Edition. John Wiley and Sons. replication,gene transcription and translation. The topics
rd
2. Page, R.D.M. & Holmes, E.C. (1998). Molecular covered: Eukaryotic genome, C-value paradox, histones
Evolution: A Phylogenetic Approach. Blackwell and non-histone proteins, heterochromatin and
Science. euchromatin, classes of DNA, DNA replication in
eukaryotes, transcription, RNA polymerases I, II and III,
SIL 2005 EVOLUTIONARY GENETICS gene regulation in eukaryotes, various control and
regulatory elements, pre-mRNA processing and alternative
This course introduces population genetics theory as the splicing, RNA processing events (rRNA, tRNA, trans-
basis of the genetic model of evolutionary change; splicing, RNA-editing), posttranscriptional control of gene
microevolution; macroevolution and the evolution of genetic expression, transcriptional regulation (DNA binding
systems. Topics include evolutionary processes in domains), and transcriptional regulation through signal
populations, molecular clocks, neutral theory, coalescent transduction pathway.
theory, species concept, speciation, co-evolution, evolution
of genomes and evolution of genetic systems. Assessment Methods:
Continuous Assessment: 40%
Assessment Methods: Final Examination: 60%
Continuous Assessment: 40%
Final Examination: 60% Medium of Instruction:
English
Medium of Instruction:
English Main References:
1. Snustad, D.P. & Simmons, M.J. (2009). Principles of
Main References: Genetics. 6th ed. John Wiley.
1. Ridley, M. (2004). Evolution. Blackwell Science. 2. Genetic Analysis and Principles (Brooker).
2. Smith, J.M. (1998). Evolutionary Genetics, Oxford 3. Other Basic Genetics text books.
Univ. Press
3. Price P. (1996). Biological Evolution, Saunders
College Publishing. SIL 2009 RECOMBINANT DNA TECHNOLOGY

SIL 2006 POPULATION GENETICS Introduction to DNA recombinant technology; basic gene
cloning and gene analysis; vector; enzymes; methods of
The course is an introduction to the concept of population DNA restriction and DNA ligation; methods to introduce
genetics for maintenance and importance of genetic foreign DNA into host cells; screening of clones; clones
variation in human, microbes, plants for biodiversity, characterisation; enzymatic manipulation of DNA and RNA;
agriculture, breeding and fisheries. The course also radioactive and non-radioactive probe labelling; Southern &
introduces the statistical programs that are needed for Northern hybridisations, colony, plaque and dot blotting;
understanding the principles of population genetics. radioactive and non-radioactive hybridisations; plasmid,
lambda & M13 phages and cosmid-vector cloning systems,
Assessment Methods: PCR; site directed mutagenesis and protein engineering;
Continuous Assessment: 40% DNA sequencing; and gene mapping. Next generation
Final Examination: 60% sequencing and technologies. Practical.

Medium of Instruction: Assessment Methods:
English Continuous Assessment: 40%
Final Examination: 60%
Main References:
1. Mathew b. Hamilton, Wiley Blackwell Publishing Medium of Instruction:
2. Principles of Population Genetics (Background). Hartl English
DL and Clark AG. Cambridge University Press 3rd
Edition 1997.
3. Genetics of Populations. Author: Hedrick. PW, Jones & Main References:
Bartlett Publishing 3rd Edition 2005 1. Brown TA 2010, Gene Cloning, March 2010, ©2010,
Wiley-Blackwell
SIL 2007 QUANTITATIVE GENETICS 2. Primrose SB, RM Twyman & RW Old 2014, Principles
of Gene Manipulation, 8th ed. Blackwell Sc.
The course is an introduction to the concept of quantitative 3. Sambrook J. & DW Russell 2001, Molecular Cloning, a
genetics for genetic improvement program. laboratory manual, 3rd ed.CSH Lab Press.

Assessment Methods:
Continuous Assessment: 40% SIL 2010 IMMUNOGENETICS
Final Examination: 60%
The course gives an understanding on the importance of
Medium of Instruction: the immune system in ensuring immunity. The introduction
English is a discussion on the cells involved in the innate and
adaptive systems. An in-depth explanation on the clonal
Main References: selection theory, rearrangement process of the receptors,T
1. Falconer, D.S. & Mackay, T.S. (1996). Introduction to cell thymic education, B cell selection and production of
Quantitative Genetics. 4th ed. Wesley Longman. antibodies/immunoglobulins will be given. The role of the
2. Hartl, T.L. & Jones, E.W. (2005). Essential Genetics. major histocompatibilty complex in processing and
Jones & Bartlett Publishers. presentation of antigens, activation and signal transduction
3. Stufflebeam, C.E. (1989). Genetics of Domestic Animals. of T and B cells and importance of cytokines regulation in
Prentice Hall. immune responses will be discussed. Important immune

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