Page 91 - Handbook Bachelor Degree of Science Academic Session 20202021

Faculty of Science Handbook, Academic Session 2020/2021

SIL 3004 ADVANCED GENETICS cell in C. elegens, sex determination in yeast, Drosophila
and mammals, genetic specification of floral organ identity
Gene mutation, the Luria-Delbrück fluctuation test, the ClB Arabidopsis, stem cell, and ethical issues.
chromosome, the Ames test for mutagenicity, trinucleotide
repeat expansion, DNA repair systems: direct repair, Assessment Methods:
nucleotide and base excision repair, mismatch repair, and Continuous Assessment: 40%
recombinational repair, sister chromatid exchange, Final Examination: 60%
harlequin chromosomes, homologous recombination: the
Holliday model, the Meselson-Radding model, and the Medium of Instruction:
double-stranded break model, gene conversion, site- English
specific recombination, transposition: Ds and Ac,
transposons: insertion sequence, complex transposon, and Main References:
composite transposon, transposon tagging, non-Mendelian 1. Developmental biology (10th edition). Scott F. Gilbert.
inheritance: maternal effect, epigenetic inheritance (dosage 2013. Sinauer Associates, Inc.
compensation and genomic imprinting - Prader-Willi 2. Principles of Development (4th edition). Lewis Wolpert
syndrome and Angelman syndrome, uniparental disomy: and Cheryll Tickle. 2010. Oxford University Press.
isodisomy and hetrerodisomy), and extranuclear or 3. Molecular Biology of the Cell (5th edition). Alberts B,
cytoplasmic inheritance (maternal inheritance, Johnson A, Lewis J, et. al. 2007. Garland Science.
pigmentation trait in plants, male-sterility trait, petite traits:
segregational petite mutants and vegetative petite mutants
- neutral petites and suppressive petites, chloroplast SIL 3007 MOLECULAR BIOLOGY OF PLANTS
inheritance in Chlamydomonas, uniparental inheritance),
evolution of the concept of the gene: function and structure, Introduction to basic principles and current advancements
the complementation test, the cis-trans test, homoalleles in plant molecular biology. This course covers theoretical
and heteroalleles, intragenic complementation, limitations and practical aspects that form the bases of current
on the use of the complementation test. approaches in plant improvement and biotechnology,
including genetic engineering. Lectures include: structure,
Assessment Methods: organisation and regulation of plant genes and cell
Continuous Assessment: 40% signalling in plant cells; molecular biology of plastids and
Final Examination: 60% chloroplasts; organisation of mitochondrial DNA; molecular
biology of nitrogen metabolism; molecular biology of
Medium of Instruction: development; cell signalling, molecular plant-pathogen
English interactions, marker assisted breeding and plant genomics.
Related practicals will be given.
Main References:
1. Principles of Genetics 4th Edition (Snustad and Assessment Methods:
Simmons). Wiley Publications Continuous Assessment: 40%
2. Genetic Analysis and Principles (Brooker) Final Examination: 60%
3. Other Basic Genetics text books
Medium of Instruction:
English
SIL 3005 FROM CELL TO SYSTEM
Main References:
This is an advanced course covering the following topics of 1. Buchanan, Grusseim and Jones (2006) Biochemistry
cellular and molecular biology of eukaryotes: revision of the and MolecularBiology of Plants, Pbls. John Wiley and
cell cycle and the molecular basis of cell cycle regulation, sons (UK) ISBN 09430088399.
apoptosis pathways, modes of cell signalling, signalling 2. Genes IX, Benjamin Lewin (2007)
molecules and their receptors, signal transduction, 3. Information in Spectrum
signalling pathways, types of cell surface
receptor, G protein coupled receptors, enzyme-linked
receptors, non-receptor enzymes in signalling and second SIL 3008 HUMAN GENETICS
messengers.
This course starts by looking at the content and
Assessment Methods: organisation of the human genome. It involves describing
Continuous Assessment: 40% the gene-related sequences (genes, introns, exons,
Final Examination: 60% regulatory regions, pseudogenes etc) and non-gene-
related sequences (unique to highly repetitive classes). The
Medium of Instruction: student is then introduced to the Human Genome Project
English and the processes involved. It includes physical and
genetic mapping. The second part will focus on the
Main References: methods of medical genetic research, with old and new
1. Krauss, et al. Biochemistry of signal transduction and techniques. This includes functional cloning, positional
regulation. Third Edition, Wiley. cloning and candidate gene approaches (functional
2. Other text books will be referred to. candidacy, positional candidacy, mutation screening
methods). At the end of the course, students will be
familiarised with current issues and research technology
SIL 3006 DEVELOPMENTAL GENETICS which includes SNP analysis, microarray and proteomics.

This course focuses on concepts and understanding of Assessment Methods:
developmental biology with an emphasis on molecular Continuous Assessment: 40%
genetics. The topics covered are: overview of animal Final Examination: 60%
development, early stages of embryonic development,
basic concept in developmental genetics, regulation and Medium of Instruction:
differential gene expression, molecular genetics of English
pattern formation in Drosophila, development fate of each

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