Page 59 - Handbook Bachelor Degree of Science Academic Session 20212022

Faculty of Science Handbook, Academic Session 2021/2022

3. Wolpert L. & Tickle C. Principles of Development, 4th
ed, 2010, Oxford University Press.
SIR3024 MICROBIAL PATHOGENESIS
The course covers host defences against infection and the SIR3027 EPIGENETICS AND GENE REGULATION
bacterial strategies in overcoming host response: virulence
factors that promote colonization of host surfaces and This course will provide a basic understanding of the role of
invasion of host cells. Regulation of virulence genes. epigenetics in gene regulation. Topics will include
Characteristics of Pathogenicity Islands, endotoxin, chromatin remodelling, histone modifications, DNA
exotoxin- characteristics of exotoxins, toxin types, secretion methylation, the importance of epigenetics in normal
and excretion systems, roles of toxins in diseases; cellular functions, evidence for epigenetics involvement in
Mechanism of antimicrobial resistance and how bacteria disease.
become resistant to antibiotics. Examples of specific
bacterial pathogens. Assessment Methods:
Practical component on laboratory skills. Continuous Assessment: 50%
Final Examination: 50%
Assessment Methods:
Continuous Assessment: 60% Main References:
Final Examination: 40% 1. Armstrong L. Epigenetics, 2014, Garland Science
2. Tollefsbol T. Handbooks of Epigenetics, 2nd ed,
Main References: 2017, Academic Press, Elsevier
1. Kenneth T. Todar’s Online Textbook of 3. Allis C.D., Jenuwein T. & Reinberg D. Epigenetics,
Bacteriology, 2014. 2nd ed, 2015, Cold Spring Harbor Laboratory Press
2. Locht, C. & Simonet, M. Bacteria Pathogenesis:
Molecular and Cellular Mechanisms, 2012, Caister
Academic Press. SIR3028 EUKARYOTIC CELL SIGNALLING
3. Wilson, B.A., Salyers, A.A., Whitt, D.D. & Winkler,
M.E. Bacterial Pathogenesis: A Molecular This is an advanced course covering the following topics of
Approach, 3rd ed, 2011, ASM Press. cellular and molecular biology of eukaryotes: in the
mammalian system, topics covered are revision of the cell
cycle and the molecular basis of cell cycle regulation,
SIR3025 CYTOGENETICS apoptosis pathways, modes of cell signalling, signalling
molecules and their receptors including G protein coupled
This course focuses on structure and function of receptors, enzyme linked receptors, non- receptor enzymes in
chromosomes, movement of chromosomes during mitosis, signalling and second messengers. In plant system, topics
modifications of mitosis, movement of chromosomes during covered are signal perception, transduction and integration
meiosis, correlation between meiosis and Mendelian laws, in plants; intracellular signal transduction, amplification and
aberrant meiosis, methods in cytogenetics, karyotype integration via second messenger and MAPK cascades;
analysis and nomenclature, variation in chromosome types, signal transduction from phytochromes; seedling
variation in chromosome number and structure. development; stomatal aperture; cell senescence and
apoptosis; and cell senescence metabolism.
Assessment Methods:
Continuous Assessment: 40% Assessment Methods:
Final Examination: 60% Continuous Assessment: 50%
Final Examination: 50%
Main References:
1. Klug W.S., Cummings M.R. & Spancer C.A. Main References:
Essential of Genetic, 10th ed, 2019, Pearson 1. Lodish et al. Molecular Cell Biology, 8th ed, 2016,
Education Inc. W. H. Freeman
2. Roy D. Cytogenetics, 2009,. Alpha Science Intl Ltd. 2. Buchanan et al. Biochemistry & Molecular Biology
3. Brooker, R.J. Genetics: Analysis & Principles, 6th ed, of Plants, 2nd ed, 2012, Wiley.
2018, McGraw Hill.
SIR3029 GENETIC BASIS OF CANCER
SIR3026 DEVELOPMENTAL GENETICS
The course gives an understanding on cancer and why it is
This course focuses on basic concepts and general seen as a much feared disease worldwide. The etiology,
principles in embryonic development, genetic approach to development and treatment of cancer will be discussed
development, genetic toolkit for Drosophila development, focusing on the genetic and molecular aspect.
spatial regulation of gene expression in development, post-
transcriptional regulation of gene expression in Assessment Methods:
development, the many roles of individual toolkit genes, Continuous Assessment: 50%
development and disease. Final Examination: 50%
Assessment Methods: Main References:
Continuous Assessment: 50% 1. Weinberg R.A. The Biology of Cancer, 2nd ed,
Final Examination: 50% 2014, W. W. Norton\
2. Pezzella E., Tavassoli M. & D.J. Oxford Textbook
Main References: of Cancer Biology, 1st ed, 2019, Oxford University
1. Gilbert S.F. Developmental biology, 12th ed, 2019. Press
Sinauer Associates Inc.
2. Griffiths A.J.F. An Introduction to Genetic Analysis,
12th ed, 2020, W. H. Freeman

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