Page 132 - tmp

Faculty of Science Handbook, Session 2017/2018

cell and organisms. Focus will be given on the pharmacological knowledge, increasing our understanding
transportation processes and cell signalling. For cell of mechanisms of drug action. The following areas will be
signalling, hormone system will be used as a platform of studied in detail; genetic variability in drug action, protein
discussion, which involve with signalling cells/tissues, the structure-activity relationships, receptor-ligand interactions,
target cells/tissues, the mode of transportation, the signal signal transduction, biochemical and molecular aspects of
transduction and the outcome of the signalling. G-protein coupled receptors and their signalling
mechanisms.
Assessment Methods:
Continuous Assessment: 40% Assessment Methods:
Final Examination: 60% Continuous Assessment: 40%
Final Examination: 60%
Medium of Instruction:
English Medium of Instruction:
English
Soft Skills:
CT3, LL2 Soft Skills:
CS3, CT3, LL2
Main References:
1. Molecular Biology of The Cells, 4th edition, Alberts Main References:
et al (QH581.2 Mol) 2002. 1. Palmer, M., Chan, A., Dieckmann, T., & Honek, J.
2. The World of the Cell, 7th edition, Becker et al (2012). Biochemical-Pharmacology (1st
(QH581.2 Bec) 2009. Edition). WILEY, U.S.
3. Biochemistry of signal transduction and regulation / 2. Bacq, Z. M. (2014). Fundamental of Biochemistry
Gerhard Krauss. 5th edition. Gerhard K. (QP517 3. Pharmacology, Elsevier.
C45Kra). 2014. Pharmacology 3rd Edition (Lippincott's Illustrated
Reviews) by Richard
4. An introduction to biological membranes: from 4. Klaassen, C.D., Casarett, L. and Doull, J. (2013).
bilayers to rafts. Stillwell W. ISBN: 9780080931289 ; Casarett and Doull’s Toxicology: The Basic Science
London; Waltham, MA: Elsevier Science, of Poisons. McGraw-Hill Prof Med/Tech
2013. ScienceDirect® e-Books 5. Rang, H.P., Dale, M.M., Ritter, J.M. and Flower, R.J.
5. The endocrine system at a glance. Greenstein B., (2007). Rang and Dale’s Pharmacology, (6th ed.)
Wood D. ISBN: 9781444332155 ; 3rd ed. ; Churchill Livingstone Elsevier
Chichester, West Sussex: Wiley-Blackwell,
2011. Ebrary e-Books. SIJ 3011 POST-GENOMIC TECHNOLOGY &
6. The Structure of biological membranes. 2nd edition BIOINFORMATICS
Yeagle P. Boca Raton, FL : CRC Press, 2005.
(QH601 Str) This course will introduce students to post-genomic era
technologies and how they are used in scientific research.
The course will focus on three main platforms –
SIJ 3008 ADVANCED MOLECULAR BIOLOGY transcriptomics, proteomics and metabolomics. Students
will be exposed to bioinformatics tools to allow them to
In the first half of the course, students will be thought understand, analyse, integrate and correlate data from the
techniques used in the manipulation of DNA and the basics three platforms. The use of these technologies in studying
of recombinant DNA technology. Topics covered would biological systems will also be explored. A brief introduction
include recombinant technologies, the use of recombinant to other post-genomic technologies (e.g. lipidomics,
technologies in gene manipulation and the basic principles glycomics, etc) will also be included. Throughout the
of the methods used. course, students will also be introduced to Bioinformatics in
data analysis and management.
In the second half of the course, the use of these
approaches in scientific research will be explored. Assessment Methods:
Assessment Methods: Continuous Assessment: 40%
Continuous Assessment: 40% Final Examination: 60%
Final Examination: 60%
Medium of Instruction:
Medium of Instruction: English
English
Soft Skills:
Soft Skills: CS3, CT3, TS2, LL2
CS3, CT3, TS2, LL2
Main References:
Main References: 1. Scientific journal papers
1. Gene Cloning and DNA Analysis: An Introduction (6th 2. Notes to be provided during lectures
Edition or later). T.A. Brown 3. Introducing Proteomics: From concepts to sample
2. Molecular Biology of the Gene (7th Edition or later). separation, mass spectrometry and data analysis
Watson, Baker, Bell, Gann, Levine & Losick (2011). Josip Lovric
3. Principles of Biochemistry (4th Edition or later). Voet, 4. Transcriptomics: Expression Pattern Analysis
Voet & Pratt (2009). Virendra Gomase
5. Metabolomics in Practice: Successful Strategies to
Generate and Analyze Metabolic Data (2013).
SIJ 3010 BIOCHEMICAL PHARMACOLOGY Michael Lammerhofer and Wolfram Weckwerth
This course will examine the molecular basis of drug action
and explore how cutting edge technology can advance

129